Key Publications

Inserm
Vauthier V, Jaillard S, Journel H, Dubourg C, Jockers R, Dam J. Homozygous deletion of an 80 kb region comprising part of DNAJC6 and LEPR genes on chromosome 1P31.3 is associated with early onset obesity, mental retardation and epilepsy. (2012). Molec Gen Metabo. 106(3):345-50.

Endospanin 1 regulates body weight and insulin secretion by differentially affecting hypothalamic leptin signaling” V. Vauthier, P. Chen, S. Migrenne, C. Sarkis, M. Lamari, C. Derviaux, M. Pagnon, T. Hosoi, J. K. Osawa, Mallet, JM Launay, C. Magnan, R. Jockers, J. Dam.
Under Review.

ICL
Beale KE, Gardiner JV, Bewick GA, Hostomska K, Patel NA, Hussain SS, Jayasena CN, Ebling FJ, Jethwa PH, Prosser HM, Lattanzi R, Negri L, Ghatei MA, Bloom SR, Dhillo WS. Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem. Br J Pharmacol. 2012 Aug 31. doi: 10.1111/j.1476-5381.2012.02191.x. [Epub ahead of print]

De Silva A, Salem V, Long CJ, Makwana A, Newbould RD, Rabiner EA, Ghatei MA, Bloom SR, Matthews PM, Beaver JD, Dhillo WS. The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans. Cell Metab. 2011 Nov 2;14(5):700-6.

Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, Becker-Pauly C, Ghatei MA, Bloom SR, Murphy KG. A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Endocrinology. 2011 Dec;152(12):4630-40.

UKK
Könner AC, Hess S, Tovar S, Mesaros A, Sánchez-Lasheras C, Evers N, Verhagen LA, Brönneke HS, Kleinridders A, Hampel B, Kloppenburg P, Brüning JC. Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab. 2011 Jun 8;13(6):720-8.

UGOT
Egecioglu E, Jerlhag E, Salome N, Skibicka KP, Haage D, et al. (2010) Ghrelin increases intake of rewarding food in rodents. Addict Biol 15: 304-311.
Skibicka KP, Hansson C, Alvarez-Crespo M, Friberg PA, Dickson SL (2011) Ghrelin directly targets the ventral tegmental area to increase food motivation. Neuroscience 180: 129-137.
Skibicka KP, Hansson C, Egecioglu E, Dickson SL (2012) Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addict Biol 17: 95-107.

UCAM
Yeo GSH and Heisler LH. (2012). Unravelling the brain regulation of appetite: Lessons from genetics. Nat Neurosci 15(10):1343-9.

Cheung MK, Gulati P, O’Rahilly S and Yeo GSH. (2012). FTO (Fat mass and obesity related) expression is regulated by availability of essential amino acids. Int J Obesity. Advance online publication 22 May 2012.

Ma M, Harding HP, O’Rahilly S, Ron D and Yeo GSH. (2012). Kinetic analysis of FTO (Fat mass and obesity related) reveals that it is unlikely to function as a sensor for 2-oxoglutarate. Biochem J 444(2):183-7.

Gumy L*, Yeo GSH*, Tung YCL, Zivraj K, Willis D, Coppola G, Lam BYH, Twiss JL, Holt C & Fawcett J. (2011). Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localisation. RNA (1):85-98. (* co-first authors).

Zivraj K, Tung YCL, Piper M, Gumy L, Fawcett J, Yeo GSH† and Holt C†. (2010). Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs. J Neuroscience 30(46):15464-78. († co-corresponding author).

Jovanovic Z, Tung YCL, Lam BYH, O’Rahilly S and Yeo GSH. (2010). Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin. J Neuroendocrinol 22(8):915-25.

Tung YCL, Ayuso E, Shan XY, Bosch F, O’Rahilly S, Coll AP and Yeo GSH. (2010). Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 5(1):e8771.

Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, Saudek V, O’Rahilly S, Froguel P, Sedgwick B, Yeo GSH. (2010). Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes 59(1):311-8.